Tag Archives: writing

by

Fear and Finials

The word finial takes me straight to Portland, Oregon and Family Medicine Residency. My grandmother loaned us the down payment for a house and we were in Southeast, on Belmont Street. The neighborhood was coming up rapidly. My son was six months old when we moved there.

Across the street were two houses owned by two couples. All four worked for the Oregon Shakespeare Festival in the summers. One woman quit and started a landscaping business. She had six foot tomato plants in her back yard by the end of the summer. She had a gorgeous flower garden in front. She also put up a decorative fence with elegant plexiglass finials.

One day all the finials were smashed. We were all sure that it was Mike. Mike lived in a duplex next to us and was terrifying. Initially it was his mother living there with a potbelly pig that would use a ramp to go down in the yard. The son moved in with his wife and child. His mother and the pig left and then the wife and child did too. Before the wife and child left, Mike knocked on my door and asked about exchanging baby sitters. I explained that we had an arrangement with someone and could not do that. After he left, I told my husband, “Don’t let that man into our house ever.”

As a neighborhood, we discussed what to do if Mike came at one of us. We figured he was on crack, he was terrifying, and we should go for head or knees, because we did not think pain would slow him down. This sounds over the top, right? Nope. My little family was in Eastern Oregon for a ten week rotation. “You missed the fun,” said our neighbors. “Mike threatened to shoot himself, they called out the SWAT team. He shot himself but he missed and only creased his head. He’s in the state hospital for six months.” Except he was back in three months. I’ve also written about him chasing his upstairs neighbor into traffic stark naked, trying to hit him with a five iron. Rush hour traffic stopped dead to watch the show.

We thought the 5 iron probably took out the finials. The owner of the house next door sold it and Mike left. We were all terribly relieved. And that is what the word finial brings up.

For the Ragtag Daily Prompt: finial.

The photograph is not from Portland, Oregon in the 1990s. It is from London in March 2022.

by

Covid 19 and the heart

This is from the University of New Mexico Roam Echo PASC (Post Acute Sequelae of Covid-19) talk on 11/9/2023 over Zoom.

Cardiovascular Outcomes in Post-COVID Conditions
Jeffrey Hsu, MD, PhD, FACC, Assistant Professor, Division of Cardiology – University of California, Los Angeles Health and Founder, COVID Cardiology Program – University of California, Los Angeles 

I am going to include the references in the order that Dr. Hsu talked about them. This is a sobering and upsetting lecture with the research showing a post Covid-19 increase in cardiovascular risk factors (cholesterol, hypertension, diabetes), and an increase in cardiovascular events in people with no previous cardiovascular diagnosis including heart attack, stroke, pulmonary embolus, blood clots and sudden death.

I don’t expect the general population to read the studies, but look at a few of them. It is very very impressive, the amount of work being done. Now let’s explore the talk and boil it down to three sentences for primary care to explain in clinic. Right. (You can always skip to the last two paragraphs if you get overwhelmed, and come back later.)

Part 1: The Research.

The first paper is about veterans without cardiovascular disease, followed for one year after Covid-19, matched with a cohort who did not have Covid-19. This is before immunization was available. They were studying the heart and cardiovascular risk. The veterans who had had Covid-19 infection were twice as likely to be diagnosed with cardiovascular risk then the veterans who had not had Covid-19. The risk was higher in the veterans with more severe Covid-19, the risk was present in all subgroups: old, young, male, female, with or without other risk factors. At two years out, the people who had been hospitalized for Covid-19 still had a persistent increased risk of death and cardiovascular incidents (heart attack, stroke, sudden death, blood clots).

To be clear, this is NOT Long Covid patients. This is just a cohort of veterans who had Covid-19. This would indicate that everyone who had Covid-19 has an increased cardiovascular risk.

Here is the first paper: 1. https://www.nature.com/articles/s41591-022-01689-3

Two more papers looked at more general populations who got Covid-19 before the vaccine was available and found the same thing. The veterans tended to be older and more male patients, but the general population studies found the same pattern in women and younger patients. Papers:

2. https://www.scientificamerican.com/article/the-risk-of-heart-disease-after-covid/, “Health modeller Sarah Wulf Hanson at the University of Washington’s Institute for Health Metrics and Evaluation in Seattle used Al-Aly’s data to estimate how many heart attacks and strokes COVID-19 has been associated with. Her unpublished work suggests that, in 2020, complications after COVID-19 caused 12,000 extra strokes and 44,000 extra heart attacks in the United States, numbers that jumped up to 18,000 strokes and 66,000 heart attacks in 2021. This means that COVID-19 could have increased the rates of heart attack by about 8% and of stroke by about 2%. “It is sobering,” Wulf Hanson says.

3.https://www.nature.com/articles/s41591-023-02521-2

Non hospitalized patients had decreased risk for some cardiovascular problems but not all and still had significantly higher risk than people who had not had Covid-19. I am busily thinking UH-OH, this is really bad, in this lecture.

He stated that the data is not in yet about vaccination, whether it lowers the cardiovascular damage compared to unvaccinated.

The initial study was on veterans, mostly male and mostly white, but then was replicated in other similar studies that were not on veterans, but on a general population.

From the second and third study, 700,000 patients with a mean age 40 and more than half female, were studied for new cardiovascular disease in the year following Covid-19 and found an increased risk of death within one year, 0.34% vs 0.28% HR 1.6. That was in 2020, a nonvaccinated population. Another study showed similar results, 13,000 patients with Covid-19 and 26,000 without, average age 51. There was a similar risk increase in cardiovascular disease and an increased risk of death within one year.

4. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00349-2/fulltext

5. https://jamanetwork.com/journals/jama-health-forum/fullarticle/2802095

So do other infections do the same thing? Studies of acute risk of myocardial infarction risk after influenza, done before the pandemic, indicate an increased risk of myocardial infarction within one week after infection, but not beyond that week. So Covid-19 is really really nasty to our cardiovascular system.

6. https://www.nejm.org/doi/10.1056/NEJMoa1702090

7. https://www.nejm.org/doi/10.1056/NEJMra1808137

Pneumonia and sepsis can increase risk of cardiovascular disease, but there have not been the extensive studies as in Covid-19. More and better studies.

One to two years after diagnosis, there is increased cardiovascular and cerebrovascular risk, both:

  1. Cardiovascular risk factors, worsening after covid
  2. Thrombosis risk

8. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00044-4/fulltext

The risk of is up diabetes 40% in the post Covid-19 patients. That does not mean that 40% are diagnosed with diabetes, but that the risk is higher after Covid-19. For example, if in the non-Covid cohort 100 of 1000 40 year olds develop type 2 diabetes, then it’s 140 of 1000 in the post Covid-19 group.

The risk of dyslipidemia in 50,000 patients went up 24%. Dyslipidemia means increased LDL cholesterol or increased triglycerides and lower HDL or all of them.

9. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00355-2/fulltext

10. https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.123.21174

Hypertension is up too and weight gain.

11. https://www.nature.com/articles/s41577-022-00762-9

New onset hypertension is up 22% in hospitalized patients post Covid-19 and 11% in unhospitalized post Covid patients.

Myocardial infarction (heart attack) and ischemic stroke both go up. Ischemic stroke is the more common kind of stroke and is the clotting version. Bleeding strokes are less common.

Why does Covid-19 do this? What is the mechanism? The studies are pointing towards thromboembolism as the mechanism in both increased cardiovascular risk factors (dyslipidemia, hypertension, stroke, heart attack, clots). Thrombosis means clots. Remember the talk about micro-clots? (My write up here: https://drkottaway.com/2023/04/14/xeno-or-infection-phobic/). Micro-clots can lead to bigger clots. A clot in a heart artery causes a heart attack; in the brain an ischemic stroke; a clot in the leg can break into pieces and block the lung arteries. Irritation in the heart and the arteries can increase blood pressure. I’m not sure how it can increase diabetes, but it does.

Next he shows a slide about thrombosis and how complex it is. Sars covid-19 seems to promote perfect storm of events that leads to environment for thrombosis in multiple ways.

Covid-19 infects epithelial cells, causes a hyperactive immune response, orchestrates subsequent response, causes platelet hyperactivation and then hyperactive innate immune response, causes damage to glycocalyx that protects and vascular endothelial injury, decreases antithrombogenic and increases prothrombogenic activity which promotes thrombosis in the vasculature, platelet activation and coagulopathy. Got that? No? Me either, my last immune system class was in 1988 when I was working at the National Institutes of Health. It’s bad, meaning it can kill us or cause damage that is disabling.

12. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30937-5/fulltext

My notes are a bit disjointed here: The endothelial cells (which line arteries) express H2 receptors that Covid-19 virus needs to enter the cells. The H2 receptors are also in glomerular capillary loops (kidneys), and immune cells and cause apoptosis of lung endothelial cells. Apoptosis is a form of programmed cell death that occurs in multicellular organisms and some eukaryotic microorganisms. So you don’t want your lung cells doing that. Lung, small bowel, and pulmonary microvasculature can all be affected.

13. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00355-2/fulltext

Plaque in human coronary vessels, in the immune cells, spike and Sars cov 2 identified in coronary artherosclerotic plaque.

Direct on coronary and cerebrovascular cells. (Ok, I don’t know what I meant by this note.)

Part II: Now what? What is our approach to healing this?

There is still limited data! (The clinical trials are roaring along but they take time.) Here are a bunch of studies, all using blood thinners. Blood thinners include aspirin, plavix, heparin, enoxaparin or apixaban. Do NOT start aspirin at home at this point, because when you add a blood thinner, there is a risk of bleeding, including bleeding stroke and intestinal bleeding. So far, the studies are discouraging.

Aspirin 150Mg Recovery trial: no difference in mortality: major bleeding 1.6% vs 1/0 % Lancet 2022. This is a double baby aspirin dose, 30 days in study, no benefit in acute setting.

14. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30937-5/fulltext

Non critically ill hosp patients ACTIV 4A trial P2Y12 inhibitor – heparin alone or clopidigril (plavix) plus heparin, no benefit, major bleeding 2.0% vs 0.7% so worse in the both group.

15. https://www.nejm.org/doi/10.1056/NEJMoa2103417

16. https://doi.org/10.1001/jama.2021.17272

Harmed patients with severe disease.

ACTIV-4B aspirin or apixiban in outpatient, stopped early, event rate low, higher rates of minor bleeding in the 5mg apixiban group.

Feedom covid 19 trial: Non ICU Hospitalized, compared prophylactic heparin to enoxaparin or apixaban. Signal to provide benefit, lower rates of death and intubation, similar bleeding rates

17. https://www.sciencedirect.com/science/article/pii/S0735109723045278?via%3Dihub

So what does our Post Covid Cardiologist recommend to physicians and patients:

First year post covid: look for cardiovascular symptoms.

Screen for risk factors, hypertension, diabetes, hyperlipidemia, obeisity.

Optimization of risk factors, smoking cessation (and I would add that alcohol also causes damage to the heart and arteries, though tobacco is worse.

Assess candidacy for statin therapy for primary prevention.

18. https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01359-7

There is a study of triple therapy (meaning THREE blood thinners) that showed improvement but that was in older patients who already have heart disease before Covid-19. So it doesn’t apply.

He says there aren’t any good studies of blood thinners in Long Covid-19 yet and it is not clear that the Long Covid people are worse as far as the cardiovascular risk than everyone else. And remember, these studies are on unvaccinated people, so for the year following the first year of Covid-19. We don’t have the results for vaccinated people. He says that if someone is high risk or has cardiac symptoms chest pain etc put on 81 mg aspirin and a statin (and work it up, of course. Do the testing.

For now use anticoagulation (blood thinners) only if there is clear evidence of thrombus: deep venous thrombosis or pulmonary embolus. Freedom covid-19 study showed major bleed risk 0.1-0.4%.

The cardiologist speaker has not started triple therapy on any patents given unknown benefit at this time, with known significant major bleeding risk. He recommends shared decision making, meaning the patient should be presented with the risks and choices. Um, ok, boil this talk down into three sentences. Good luck. EEEEEEE!

Part III: Summary.

Whether you had Covid-19 before being vaccinated or after, or aren’t sure if you ever had it, it is worth seeing your provider to check your blood pressure, do diabetes screening, stop smoking (anything, and I include vaping in that), reduce or eliminate alcohol, keep your weight reasonable, check your cholesterol and go to your provider if there is any weirdness post Covid-19. And if you have not been vaccinated, oh, my gosh. Unless you have an immunology problem where your immunologist says “NO!”, get vaccinated.

Lastly, I’ve heard many claims that death rates were “over reported” for Covid-19. No. In a death certificate, the acute injury or infection is reported FIRST and then other related causes. Such as: Covid-19, ischemic stroke, hypertension, tobacco overuse syndrome. There were MORE strokes and heart attacks and sudden death, with Covid-19 as the final straw in many people who already had cardiovascular disease. They died sooner than they would have if not infected. That is not over reporting.

____________________________________________________________________________

A friend, Brent Butler, took the photograph, used with permission. I think it shows how I felt after this talk. Yet I still have hope, because you can’t deal with something unless you know about it.

If you want a link for the talks, message me. Anyone can tune in.

Covid-19 continues to fandangle us. There. I verbed the Ragtag Daily Prompt: fandangle.

by

Tamped

The Ragtag Daily Prompt is “trial by fire“.

Which makes me think of the wars, ongoing and restarting, and the fire and death. What do we get out of killing children? Burning homes and families. I don’t understand. Revenge? To “teach a lesson”? I think it will only teach more hate.

So this morning I am listening to the Bach Magnificat and then the Rutter Magnificat. Tamp the flames of hate and lift my voice in song and may the world work towards peace. I light my candles in the early morning in prayer for us all.

by

N is for Normal.

I am blogging A to Z about artists, particularly women artists and mostly about my mother, Helen Burling Ottaway.

My family was not Normal. No, no, not normal. I don’t think anyone is normal, really. In clinic one year I think, wow, all of my people are SO interesting. Why am I so lucky to have all of these wonderful people? And then I think: OH. Everyone is interesting. No one is “normal”. They may try really hard to pass for normal. I certainly had MY work cut out. And why is that, you say. I am so glad you asked that question!

My parents were both obsessed. My mother was obsessed with art. With music, a secondary joy. My father was all about music. Mathematics and language was his secondary joy. By age nine I discover poetry and that is it for me. That is the be all end all. I am so obsessed that I am amazed at age 40 when I make a discovery: poetry is not it for everyone.

I am fired by the hospital for fighting a clinic quota of patients. I might have kept the job if I had shut my mouth and been diplomatic, but I was not diplomatic. I write a protest song and sing it at the open mike and sing it into the CFO’s voicemail. I think I could be the poster girl for the opposite of diplomatic, right?I thought about quitting and then thought, no, I stay and fight this for my patients. I am fired the next day.

A group of people try to intervene and get me rehired. At some point I suggest sending one of my poems to the hospital commissioners. Six people email: NO!

I am confused: What do you mean, no? Why not?

YOU DO NOT COMMUNICATE WITH HOSPITAL COMMISSIONERS VIA POETRY.

I am still confused: I communicate by poetry. Poetry is the highest form of communication.

HOSPITAL COMMISSIONS DO NOT LIKE OR UNDERSTAND POETRY.

Ok, THAT is mind blowing for me. I call my father. What is this about?

My father says People are afraid of poetry.

I say You are kidding me.

My father says Poetry is magic. People are afraid of magic.

I say I’m not afraid of poetry.

That is because you are a poet, says my father.

And I really look at my thoughts on writing and poetry. I realize that writing and poetry are SO IMPORTANT to me that I assume that EVERYONE WANTS TO WRITE AND BE A POET. I ask my group of people trying to get me reinstated. None of them want to be poets. I ask my father. He does not want to be a poet. I am completely floored. I realize that I thought my mother loves art but wants to be a poet. My father loves music but wants to be a poet. Wrong. Wrong, wrong, wrong.

It must have been rather weird for my sister Chris, three years younger. She has three people who are all obsessed with their form of art. My sister Chris was a brilliant writer, an excellent musician and an artist. But I don’t think she was obsessed with any of them the way the rest of the family was. That must have been a little lonely.

The photograph is me and my sister in 1965. I am four and she is one year.

I say to a counselor once that in spite of alcohol problems in the family, the music was amazing and my sister and I learned it. The counselor replies, “Children connect with adults where they can.” I think OH. That is amazing. My sister and I see my father praise my mother for knowing all the words to the songs. She is always be the last one singing because she knows verse 8, 9 and 10. My sister and I assume that this is a woman’s job: memorize the words. We did. We photocopy the back of Beatles albums and on long car trips we memorize ALL THE WORDS. I think I can still sing Yellow Submarine start to finish.

I start school. I know there will be singing. No one knows my songs. The songs they know are the songs to television shows and we do not have one. I quickly go silent. I play flute and I sing all the songs in my head when I am bored, but I do not sing out loud. And I choose medicine because I want to understand people, for the writing. I still think people are very very weird. But I have written the whole time, every single day. And that is how my mother did art and how my father did music. Every single day.

ATOZBLOGGINGCHALLENGE2022 #art #Women artists #Helen Burling Ottaway #ATOZCHALLENGE #APRILATOZ

For more information about the #AtoZChallenge, check out this link

by

vast

Sometimes emotions are vast. I do not think our culture deals with grief very easily. Grief then becomes a vast pit, stuffed inside us. I sent the Falling Angels poems to friends and family. One older friend said that the poems were too sad and was I that sad all the time?

I replied, no, I am not sad all the time. The sadness is in the poems because there are very few people that I know that are comfortable with sadness and grief. So I put it in to poetry, because I do not want to stuff it. We need to let grief come out and let the tears flow and let it go.

For the Ragtag Daily Prompt: vast.

by

copyright

For the Ragtag Daily Prompt: copyright.

This is my sister being a goofball on Christmas morning in 2010. The puppet was a family gift that we all played with. The Christmas hat is mine. This was after her cancer recurred: she died in March of 2012.

My sister wrote on line. She wrote at everything2.com and a blog: http://e2grundoon.blogspot.com/.

After she died, the people who write on everything2 were notified that another blogger had stolen multiple write ups and posted them on a blog as their own writing. That is a violation of copyright. And it feels particularly painful when it is my sister’s writing, who is dead at 49 from cancer. I do not think nice thoughts about the thief and I hope that the person regrets and makes penance for what they did. Hundreds of write ups were stolen from all sorts of people.

That is what the word copyright brings up. Don’t steal. Don’t steal my work or photographs or my sister’s or anyone else’s….