Hormones and rabbit holes

Medicine is confusing right now. Ok, it is always confusing because we try to base it on science and science is always changing. There are always special areas that are currently a mess. Hormones!

I speak to a patient recently who is female, premenopausal, and is getting hormone replacement therapy for hot flushes and not sleeping well from an outside source. The person wants me to order hormone tests. I do order hormone tests but not the ones she has in mind. I test a TSH, thyroid stimulating hormone, to see if she is low or high in thyroid.

She is thinking of me testing estrogen and progesterone and other related hormone levels. The party line from gynecology MDs and DOs is that these are not useful tests because women’s hormone levels are so varible. However, there are lots of naturopaths out there and functional medicine MDs and DOs who will test levels. Why is the patient asking ME to test them? Most of those naturopaths and functional medicine providers do not take insurance and charge cash. Also, insurance may not pay for them anyhow because the party line is that they aren’t useful. Why would the cash providers check levels? One reason is CASH. Another is to prescribe “bioequivalent hormone replacement”. Sounds natural, right? Well, the natural thing was for the hormones to stop at menopause and all of the hormones are either made in a laboratory from plant pre-estrogens or from pregnant mare urine, so bioequivalent seems to imply natural but it really isn’t. Pills do not grow on trees, they are made by humans in laboratories.

However, I question party lines, and off I go down the hormone rabbit hole. The current guidelines are that female hormone replacement, after menopause, should be lowest dose possible and only for a maximum of three years because of the increased risk of breast cancer. This doesn’t address my question: does premenopausal hormone replacement count as part of those three years? I may need to ask gynecology. I don’t think it counts. A woman is postmenopausal when she has had no periods for a year. Or had her ovaries removed. Or if she’s had a hysterectomy and still has her ovaries, a yearly follicle stimulating hormone and lutienizing hormone test. Both tests rise when the ovaries stop making hormones and eggs.

Also, there is another caveat. We know that when men are on opioids, the opioids can suppress their hormones and lower testosterone. Here is a paper: https://pubmed.ncbi.nlm.nih.gov/31511863/. Half the men studied in multiple studies had low testosterone when on chronic opioid therapy. 18429 subjects (patients) in 52 studies. That is a lot. Women studied? NONE. What? Yeah, none. Why? Here is part of the answer: about a decade ago I worked with the UW Telepain group and asked the head of the UW Pain clinic a question. “If opioids lower hormones in men, do they in women too?”

His reply, “I don’t know.”

“Have you ever tested a woman?”

“No.”

“Isn’t that sort of sexist?”

“Yes.”

So here I am, rechecking a decade later, and we still don’t know if giving women chronic opioids messes up their hormone levels. It would be more complicated and difficult to check women. We might have to do individual hormone baselines or something in premenopausal ones, say, 2 weeks after menses. Remember that for most of the history of medicine, clinical drug trials were only done in men, because, well, sexism. They said women could get pregnant. Yes, but then we gave the drugs to women who could get pregnant. Also, postmenopausal women can’t get pregnant. The whole thing seems stupid to me.

There is an interesting new finding here: https://neurosciencenews.com/estrogen-t-cells-pain-28548/ . Apparently in women, estrogen and progesterone work on receptors at the base of the spine to reduce pain signals using T cells, part of the immune system. The article says this doesn’t happen in men, but they were studying mice. The male mice didn’t seem to have worse pain after estrogen and progesterone were blocked. The female mice were in more pain. But wait, estrogen and progesterone are produced in men as a by product of making testosterone. Less than women, until menopause. Then the 70 year old man has more estrogen and progesterone than his postmenopausal wife. The article says that they don’t know why the receptors are in women and female mice (um, my intuitive guess would be childbirth and micebirth, right? Men don’t do that and women giving birth to a child after the first one sometimes say, “WHY did I want to do THIS again?” I think those receptors are so that women and mice can get through more than one pregnancy.) Now I need to read the article again because maybe men and male mice don’t have the receptors, even though they do have some estrogen and progesterone. Maybe they just don’t have enough estrogen and progesterone.

Maybe we can’t figure out women’s hormone because men aren’t smart enough, heh, heh. Yes, that is sexist right back at all those historical figures who didn’t study women.

At any rate, that still doesn’t answer my two questions: does premenopausal hormone replacement count towards the three year total beyond which hormone replacement increases the risk of breast cancer? And does chronic opioid treatment lower women’s hormone levels?

_________________

For the Ragtag Daily Prompt: hormone.

I took the photograph of a Port Townsend rabbit in 2011.

Concord

my heart is broken
love doesn’t conquer all
unselfish love
unreturned
unrequited
opens me to wound after wound
some turn from love no matter what
cling to the lies they tell themselves
cling to the poison they embrace
turn from love into the uncaring bottle
turn from love into the insensate smoke
turn from love even to the grave

I wish my heart would let them go
and heal

__________________

My friend Liz took the photograph, half way through the Rainshadow Chorale concert last Sunday.

Listen

There is anger and blame and silence.
People talk about each other.
People talk about others.
What is truth? What is rumor?
No one wants to listen.
They want to blame.

I do not see
I do not feel
I do not hear
how to heal this, Beloved
if no one will listen.

Only love.
Anger drains away.
I send love
Into the anger
Into the blame
Into the echoing silence.

On guard

My nurse’s breath catches. “Oh, no,” she says.

I am new here. Less than a year. “What?” I say.

“We have Janna Birchfield on the schedule.”

“Who is Janna Birchfield?”

Tonna leans back in her chair at the nurse’s station, a high set desk that runs behind the front office. We have new glass barriers along it to make it more hipaa compliant. It is also more claustrophobic. She throws her pen down. “She’s one of the most hostile people here. She’s known for throwing a brick through her second doctor’s plate glass window.”

“Ah,” I say.

“She was Dr. M’s patient but apparently she and Dr. K got in a screaming fight in the hallway. She is banned from that clinic. So we are the last clinic in town.”

My nurse knows the local stories and she has seen a lot. She doesn’t have a lot of unconscious monsters. Yeah, there is some impatience and some anger there, but she’s pretty good. No real fear, nothing cringing at her feet.

“Hmm. Let me talk to Marnie.” Marnie is our office manager.

Marnie and I talk. I read the last notes from Dr. M and an account of the screaming fight with Dr. K. I call Dr. K. I don’t know of anything that scares her and she is tough. I rather enjoy envisioning her yelling back at this patient.

The day arrives and Mrs. Birchfield is put in a room. Vitals are done. I go in.

Janna Birchfield is big. She weighs about twice what I do, and it’s muscle rather than fat. She looks solid. Not like a body builder, just strong. She tops me by nearly a foot. She looks sullen and unfriendly.

And I am looking at her monsters. Three are guarding a fourth, at her feet. Fear is there, anger is the biggest and posturing, like a body builder, in front. The third is morphing back and fourth: envy and hostility. The fourth is in a stroller, guarded by the other three. Asleep? Unconscious? Well, yes, duh, but it’s not often that a monster is so undeveloped that it is still an infant. Not good.

“Hi, Miz Birchfield. I am Dr. Gen.” I hold out my hand, moving slowly and smoothly. Her monsters alert, fear flinching and anger ready to punch. I stand with my hand out. She eventually touches it, glaring.

“Hi,” sullen.

“We need to talk about the clinic rules first.” I say calmly. Anger puffs up and her shoulders rise as the monster swells and takes control, her elbows rising and hands are fists. Her eyes don’t turn red, but nearly. “I have heard about your argument with Dr. K.”

Furious voice, “She screamed at me. She’s a horrible doctor! She got me thrown out!”

I am smooth and calm, “I am not going to discuss Dr. K,” I say. Honestly, it’s even more fun to think of Dr. K taking this on and not budging an inch. Dr. K is my size, small. “In this clinic, I need you to understand that you are not allowed to yell at anyone at the front desk, in the hallways or on the phone.” Anger flees immediately, small again and she looks confused. “You may not yell at the staff, at the other patients, or at anyone on the clinic property.”

“Why would I agree to that?” she says. She is mostly confused because I am not scared or angry. I am not behaving the way she expects, the way most people behave around her.

“If you are upset, the only people you can yell at are me or the office manager and you need an appointment.”

“They are rude to me!” Basically she means everyone. “You can’t make me do that!”

“Take it or leave it.” I say. “You need to agree and keep the agreement, or we will discharge you immediately. If you say no, leave now, and I won’t charge for the visit.”

Her monsters are confused. Anger has shrunk back down and they are conferring, heads together. Confusion has shown up as well, morphing though different colors and stripes, stars and paisleys. She stares at me, frozen hostility. I just wait, sitting in front of my laptop, serene. This is going well. She isn’t yelling and she hasn’t left.

“What if they are mean?” she says.

“You will make an appointment with me or the office manager, and we will help you.”

“Ok,” she says. The monsters are still surrounding the carriage, but really, now confusion is in charge. We work through the rest of the visit, as I get to know her a little. She has had a hard, hard life.

I let the front office and the nurses know the rules. The office manager and I let them know that this is a contract with the patient and she has agreed. They feel protected. They feel protected enough that they are nice to her. She behaves and starts, infinitesimally, to relax. She is still angry and hostile in the exam room but it’s not directed at me. It is directed at the entire world, the rest of the world outside the clinic. I try to help her medically but also let the monsters have their say. The visits start with anger and hostility but tend to subside into confusion. I am not getting at the fear or whatever is in the stroller. It is one of the large old fashioned ones, heavy, navy blue, where an infant can lie flat. Clearly it does not fold up to go in a car or anywhere else convenient. There are no toys hanging from the top or across it, no stuffed animals. Only a form under the blankets, always still.

I may reach that form, or not. I do not know.

For the Ragtag Daily Prompt: paleontology.

Travel risks

The President is withdrawing the United States from the World Health Organization. https://www.whitehouse.gov/presidential-actions/2025/01/withdrawing-the-united-states-from-the-worldhealth-organization/

Here is the link to write to the President: https://www.45office.com/contact/

I am writing daily, just not for the Ragtag Daily Prompt. Here is my short note today:

Dear President Trump: I strongly disagree with withdrawing the United States from the World Health Organization. One function of that organization is travel clinics. If a person is traveling to another country, they can find out what illnesses are present there and get immunizations and advice to avoid getting ill. This also helps physicians treat people who have returned from another country. The physician can contact a state health department which is in turn connected to the World Health Organization. This is a foolish, dramatic and unscientific decision on your part. I suggest that you reverse it immediately or resign as President.

________________

The question I have, is he closing the borders to United States citizens too? Without the travel clinics, who get information about each country from the World Health Organization, aren’t even our own state department employees at higher risk for illness? My son was an exchange student to southern Thailand. At the time he went, there was Japanese encephalitis. He was there two years after the tsunami. He got vaccinated for Japanese encephalitis before he went and he also took medicine to avoid malaria. So, are we not going to send or accept any more exchange students?

I strongly disagree with the decision to leave the World Health Organization and our country is on the verge of crazy.

For the Ragtag Daily Prompt: verge.

Tea bear

My friend C. is a bear.

People don’t know she is a bear. She carries a bear, a teddy bear. It is named S Bear, after her husband. He died of cancer a while ago. So she carries a bear named after him. The first time I met the bear, I asked if it needed a teacup too. Because people make clothes for it and I don’t know how far it all goes. No, the teddy bear did not need a teacup.

My friend C. is a bear. She writes horror stories under the name lostcauser. The writer is from Tennessee and so is C. The stories are horrid. Lostcauser is an anagram. Rearrange the letters and you get closet ursa. Closet bear. Hidden bear.

She is not my only friend who is a bear. She is aware of her bearness, her ferocity, the beast inside. Bears like honey and blueberries, too, they aren’t just monsters. My other friend dreams of a one room shack in the woods. His dead brother is at the door shouting for help. His brother is being attacked by a bear. A huge terrifying bear.

“Did you invite it in?” I ask.

“It’s a BEAR.” says my friend.

“It’s a Dream Bear.” I say, “I would ask what it wants.”

“You don’t understand bears,” says my friend.

“I understand a lot about dreams. Some think that everyone you see in a dream is a part of yourself. It can be a part that you don’t accept.”

“Bears attack. You can’t invite them in.”

“I would ask the bear in. I would ask the bear if it would like some tea.”

I tell another friend about one of my dreams. There are monsters screaming. I go towards them.

“TOWARDS them?” says my friend. “Why would you go TOWARDS them?”

I have to think about it. “Well, they are screaming. They might be hurt. They might need medical care. I have to go help them.”

My friend shakes his head. “Only you,” he says, “would go towards the screaming.”

One time in my neighborhood, I hear horrible screaming. I get up. It is 1 am. I go out and try to find the screamer. I don’t find anyone. A few days later, I read that someone nearly severed their arm somehow, in my neighborhood. A policeman saves his life with a tourniquet. It was three blocks from my house, at the grade school. The grade school is where I went. I think the person was knifed, but I don’t know. My neighborhood does not get a lot of that sort of thing, at least, not a lot of screaming that wakes me up.

I wonder about my friend that is attacked by a dream bear. A bear that is much bigger than his dream self and his dream brother self. There must be a lot of darkness in that bear. It is angry about being ignored.

My friend C. is a bear. She knows she is a bear. Reading her stories, I do not think she likes being a bear.

I don’t mind if she is a bear. I wonder if we will have tea again some day.

____________________

For the Ragtag Daily Prompt: fan. Why? Maybe I am a fan of bears. Or maybe fans make me think of hats and gloves and tea parties. And bears.

This is based on speculation and some true events.

All of my patients are smart 3

Human behavior doesn’t surprise me, really. Sometimes it disappoints, depresses, demeans, dispirits and demoralizes. And it’s not the patients. It is the corporate workplace and how it abuses people. And circles the wagons against a threat. Including against employees that it views as threats.

I think all of my patients are smart. “You got this,” I say. I explain what carbohydrates are and that they are in everything, practically, except meat and oil. And some meats have carbohydrates too: shrimp, for example. But my patients can figure this out! My patients rise to the occasion! I am not saying that they do smart things all the time. No one does, including me. Even the smartest ones can do things that are not a good idea or are a really bad idea. Growing up in an addiction household, I think I escaped addiction mostly because I had decided that no adults could be trusted by the time I was three. I thought they loved me but I couldn’t trust them not to give me to someone else. Ironic, that the distrust saved me from taking the same path. My sister took it and is gone. My patients are smart and all I have to do is share my education and experience! They take the ball and run with it! Not all. Sometimes it’s too late and everyone dies eventually.

Corporations, on the other hand, are infuriatingly stupid.

The photograph is me in 2015, sailing my father’s boat with my daughter, in Port Townsend Bay.

Something

Something is happening all around me
Something unpleasant is creeping around
I trust that feeling, that core that is free
I go quiet and listen, I will stand my ground
I am told no problem, this is routine
Nothing to worry about, averting their eyes
Lay down and be walked on, take it for the team
Blind-sided, I walk through a jungle of lies.
I walk very slowly then take to the trees.
I swing on a vine past the river of tears.
Wave to the gators with teeth to eat me,
Routine bad treatment not surprising nor feared.
In the treetops I sing to the stars quite alone
I am happy and making my quiet way home.

Suddenly I am thinking about home. Travel does that sometimes.

For the Ragtag Daily Prompt: travel.

Masks and selfs

I call a friend yesterday and sing, “Happy Day Before Your Birthday to You”. It sounds silly. She has just gotten Covid and this cheers her up.

She is telling me about her summer and about a class at a camp. Some for adults and some for children, but one where people really dropped their masks and just got to be themselves.

What identity is your deepest self? She is talking about her nine year old self. I think mine is more like four and rebellious and skeptical of adults, adulthood and all of their rules. I don’t think I am ever out of touch with this identity, though I don’t let it talk out loud in clinic. Mostly. A rebellious four year old informed by medical school and years of experience is a pretty frightening thought, isn’t it? Or the basis for a great cartoon.

That part of me is very observant and quite smart. It does not care what we are supposed to see or the cues people give. Growing up in an alcohol household, it looks for what people do not say. This can be terribly helpful in clinic and also a bit weird. It is body language and tone of voice and what questions a person shies away from answering and the puzzle pieces that do not fit.

Last week I see a small child with her parents for vomiting and coughing and fever. I am interviewing the child and asking if things hurt. “Do your ears hurt?” I ask. She shakes her head no. I point to my throat next and she nods. Yes, that part hurts. Her toes do not. I include toes or something silly to find out if the child is saying yes to all of it. I tell the parents that we will do a strep test, that mostly people don’t cough with strep except when they do. The strep is positive. My medical assistant grumbles, “They didn’t tell me that,” but I think the parents were more worried about the vomiting and she may not have complained about her throat.

Are the masks we wear always bad? I don’t think so. I think it is frustrating if we believe our mask or never ever get to drop it. There is some formality to my role in clinic and I tend to get more formal when I am worried about someone. That has been interpreted as anger or brusqueness, but it isn’t. I am wearing a real mask with all patients because we are seeing at least one person with Covid every week. The literal mask does not help me connect with people, but sometimes I can anyhow. I have to take it off for the 90 year olds because most of them are hard of hearing and lip reading helps.

For the Ragtag Daily Prompt: identity.

I hiked the Beaver Brook Trail this weekend with my daughter.